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Oryx and Crake is a 2003 novel by Canadian author Margaret Atwood. She has described the novel as speculative fiction and adventure romance, rather than pure science fiction, because it does not deal with things "we can't yet do or begin to do", yet goes beyond the amount of realism she associates with the novel form. It focuses on a lone character called Snowman, who finds himself in a bleak situation with only creatures called Crakers to keep him company. The reader learns of his past, as a boy called Jimmy, and of genetic experimentation and pharmaceutical engineering that occurred under the purview of Jimmy's peer, Glenn "Crake".

The book was first published by McClelland and Stewart. It was shortlisted for the 2003 Man Booker Prize for Fiction, as well as for the 2004 Orange Prize for Fiction. Oryx and Crake is the first of the MaddAddam trilogy, followed by The Year of the Flood (2009) and MaddAddam (2013).

In 2023, the Hessisches Staatstheater Wiesbaden premiered an opera based on the novel, composed by Søren Nils Eichberg, conducted by Albert Horne and directed by Daniela Kerck.